Uptake by Retinal Pigment Epithelial Cells
نویسنده
چکیده
Uptake of Ca was studied in isolated frog retinal pigment epithelial cells. Ca accumulation was found to be a saturable, temperature-dependent event. Kinetic analysis of this accumulation revealed two transport systems with apparent km of 2.0 and 0.3 mM. We found the presence of a Na-Ca exchanger mechanism that releases Ca under depolarized conditions. Light induced an increase of Ca uptake due to activation of the Na-K-ATPase and consequent decrease of extracellular potassium concentration. Invest Ophthalmol Vis Sci 30:2114-2117,1989
منابع مشابه
تمایز سلول های بنیادی پرتوان به سلول های اپیتلیوم رنگدانه دار شبکیه چشم،راهکاری برای درمان بیماری های تخریب شبکیه
Pluripotent stem cells as the cells with a capacity for self-renewal and differentiation into various specificcell types have been highly regarded in regenerative medicine studies. To repair the eye disease damages, thedifferentiation into retinal pigment epithelial cells of pluripotent stem cells has gained great importance inrecent decades because the inappropriate function of these cells is ...
متن کاملExtremely low frequency-pulsed electromagnetic fields affect proangiogenic-related gene expression in retinal pigment epithelial cells
Objective(s): It is known that extremely low frequency-pulsed electromagnetic fields (ELF-PEMF) influence multiple cellular and molecular processes. Retinal pigment epithelial (RPE) cells have a significant part in the emergence and pathophysiology of several ocular disorders, such as neovascularization. This study assessed the impact of ELF-PEMF on the proangiogenic features of RPE cells. Mate...
متن کاملUptake of retinol and retinoic acid from serum retinol-binding protein by retinal pigment epithelial cells.
Isolated pigment epithelial cells from bovine eyes were shown to be capable of taking up retinol and retinoic acid. The uptake was dependent on the ligands being presented to the cells as complexes with serum retinol-binding protein. Neither free retinol nor retinol or retinoic acid presented as serum albumin complexes were taken up by the pigment epithelial cells. The transport of retinal and ...
متن کاملSynergistic suppression of retinal pigment epithelial cell proliferation in culture by radiation and hyperthermia.
PURPOSE To study combination effects of radiation and hyperthermia on the in vitro cell proliferation of cultured human retinal pigment epithelial cells; to explore possible application of the combination treatment for proliferative vitreoretinopathy. METHOD Cultured human retinal pigment epithelial cells were treated by radiation, hyperthermia, or a combination of the two. Cell proliferation...
متن کاملMorphological changes in injured retinal pigment epithelium and photoreceptor cells after transplantation of stem cells into subretinal space
Introduction: Degenerative retinal diseases are main cause of irreversible blindness. Stem cells therapy is a promising way in these diseases. Therefore, mesenchymal stem cells because of its safety can produce degenerated cells and can play important role in treatment. The aim of this study was to examine morphological changes in injured retinal pigment epithelium (RPE) and photoreceptor cells...
متن کامل